The long-running ABC soap ‘One Life to Live‘ will meet its death Friday, signing off after 44 years on the air. Like many daytime serials, ‘OLTL,’ which premiered in 1968, served as a launching pad for many stars.

Here’s a look at just some of the A-listers who used the drama as a springboard to the big time.

Hayden Panettiere

Marcia Cross

Nathan Fillion

Laurence Fishburne

Tommy Lee Jones

Ryan Phillippe

Phylicia Rashad

Blair Underwood

Judith Light

Tom Berenger

Dan Lauria

Roma Downey